Hemichorea-Hemiballismus as a Presentation of Cerebritis from Intracranial Toxoplasmosis and Tuberculosis

Background: There is limited literature documenting hemichorea-hemiballism (HCHB) resulting from co-infection of toxoplasmosis and tuberculosis (TB) in acquired immunodeficiency syndrome (AIDS). Toxoplasmic abscess is the most common cause while TB is a rare etiology. Case Description: We describe a 24-year-old male with AIDS-related HCHB as the presentation of cerebritis on the right subthalamic nucleus and cerebral peduncle from intracranial toxoplasma and TB co-infection. Antimicrobials and symptomatic therapy were given. Marked improvement was seen on follow-up. Discussion: HCHB may be the initial presentation of intracranial involvement of this co-infection in the setting of AIDS and is potentially reversible with timely management. Highlights: Hemichorea-hemiballismus (HCHB) may be an initial presentation of intracranial involvement of concomitant toxoplasmosis and tuberculosis causing focal cerebritis in the contralateral subthalamic nucleus and cerebral peduncle, particularly in the setting of human immunodeficiency virus infection. Acquired immunodeficiency syndrome-related HCHB is potentially reversible with timely diagnosis and treatment.


INTRODUCTION
The prevalence of movement disorders among human immunodeficiency virus (HIV)-infected adult population ranges from 2% to as high as 44%, with hemichoreahemiballism (HCHB) being one of the most common presentations [1]. HCHB is a hyperkinetic movement disorder characterized by involuntary, irregular movements of variable amplitude affecting one side of the body [2]. Although the two phenomenologies share a similar pathophysiology, proximally predominant, high-amplitude movements are ascribed to ballism, while more distal, lower amplitude movements are often termed chorea [2,3]. HCHB in this population is almost invariably caused by a mature toxoplasmic abscess in the subthalamic nucleus (STN) [1,4] in a Toxoplasma-seropositive patient and often in the setting of established acquired immunodeficiency syndrome (AIDS) [1,4] as summarized in Table 1. However, because the diagnosis of toxoplasmosis is often presumptive [31] and the imaging findings are non-specific [32][33][34], other common opportunistic infections that may cause the movement disorder must also be considered [4]. HIV-infected adults are 21-37 times more likely to acquire tuberculosis in particular [35], and those with systemic TB are five times more predisposed to have central nervous system involvement [35]. Although rare, HCHB may be secondary to intracranial TB complicated by infarctions, TB abscess or tuberculomas as seen in Table 1 [25,28]. There is limited literature documenting HCHB as a result of opportunistic co-infections of toxoplasmosis and TB in HIV/ AIDS patients. Here, we present the atypical case of an adult male with AIDS-related HCHB as the initial presentation of intracranial involvement from these infections. A 24-year-old man presented in our emergency department with a three-day history of involuntary movements of the left extremities. These were described as non-suppressible, mildly disabling, relieved by sleep, and rapidly progressing in frequency and amplitude. Few hours prior to admission, the movements became more violent and involved his left lower limb making ambulation difficult. There were no changes in sensorium nor other focal symptoms. He was diagnosed two months earlier with HIV infection after presenting with weight loss, fever and draining cervical lymph nodes. Lymph node biopsy revealed positive acidfast bacillus (AFB) smear while his chest radiograph was consistent with pulmonary TB, for which he was started on isoniazid, rifampicin, pyrazinamide and ethambutol (HRZE). His family, medication and toxicologic history were unremarkable. On examination, he was cachectic, tachycardic, normotensive and afebrile. He had multiple, non-tender right cervical lymph nodes with scanty serosanguinous discharge. He was awake and conversant, but had subtle difficulty following complex commands. Funduscopic examination was normal with no evidence of Kayser-Fleischer rings. Cranial nerve examination did not show any abnormalities nor facial involuntary movements. He had random, purposeless, dance-like, intermittently flinging movements of the left extremities that resulted in shrugging and internal rotation of the shoulder, as well as random flexion-extension and pronation-supination of the distal upper limb. His gait was interrupted by sudden, irregular internal rotation of the hip, flexion-extension of the knee, and inversion-eversion of the foot (Video, Segment 1). These movements were consistent with left HCHB. His limbs were normotonic with 4/5 motor strength on the left extremities. The rest of the examination was normal.

CASE DESCRIPTION
On laboratory testing, he had leukopenia with a peripheral white blood cell count of 4.2 × 10 9 /L and a peripheral blood smear showing slight poikilocytosis with no acanthocytes. He had elevated erythrocyte sedimentation rate at 121 mm/hour (normal values [NV]: 0-15) and C-reactive protein at >12 mg/L (NV: <6). He had mild hyponatremia with a sodium of 133 mmol/L (NV: 137-145 mmol/L), while his random blood sugar, liver, kidney and thyroid function tests were normal. His chest radiograph revealed bilateral apical nodular infiltrates, while abdominal imaging was unremarkable. Given the aforementioned past history, we investigated for possible infectious etiologies of the patient's HCHB. He had a positive HIV Western blot test assay and a CD4 count of 92/ mL on admission. His serum toxoplasma IgG was markedly elevated at >300 IU/mL (NV: <8) while syphilis and antistreptolysin O (ASO) titers were negative. Cranial magnetic resonance imaging (MRI) revealed a focal cerebritis in the right STN and right cerebral peduncle (Figure 1, A-D) as well as a left frontal abscess formation (Figure 1, E-H). A lumbar puncture was performed with an opening pressure of 20 cmH 2 0 (NV: 8-18 cmH 2 0). His cerebrospinal fluid (CSF) was acellular with protein at 89 mg/dL (NV: 12-60) and glucose at 45.45 mg/dL (NV: 40-70), the latter being 29% of the serum level. CSF TB polymerase chain reaction (PCR) was positive while CSF culture for M. tuberculosis had no growth. CSF AFB smear, cryptococcal antigen, bacterial and fungal cultures were all negative.
With these clinicoradiologic findings, we managed him as a case of acute left HCHB secondary to a right focal cerebritis from concurrent presumptive cerebral toxoplasmosis and definite intracranial tuberculosis. He was immediately started on oral trimethoprim/sulfamethoxazole (TMP/SMX) for the toxoplasmosis. His anti-TB regimen consisted of HRZE for two months and isoniazid/rifampicin for 10 months. To address his ballistic movements, he was given risperidone which was titrated up to 2 mg/day. His HCHB were most evident during his waking hours and remained of moderate severity, necessitating measures to avoid limb injury. He was discharged after three weeks on the previously described treatment regimen, with minimal change in his HCHB. At onemonth follow-up, we noted significant reduction in his HCHB. Due to the evident clinical improvement, TMP/SMX dose was reduced at two months after discharge. Antiretroviral therapy was started during this time, while his anti-TB medications were continued. A surveillance cranial contrast-enhanced computed tomography (CT) was done after four months of treatment demonstrating complete resolution of his cerebral lesions. At ninth-month follow-up, there were only occasional mild, non-disabling choreoathetoid movements of the left arm (Video, Segment 2), allowing discontinuation of risperidone. Figure 2 summarizes the timeline of events and the management done.

DISCUSSION
Our case affirms the characteristics of HCHB among reported cases of chorea-ballism in HIV-infected adults [1,4] namely, the (1) presence of an identified structural pathology in the contralateral STN and midbrain believed to cause the chorea,  only been seldom reported [7, 10,15] and finally, (6) the eventual clinical and radiologic improvement seen [1,4]. To our knowledge, our case is the first to document HCHB associated with cerebral toxoplasmosis that is in conjunction with intracranial TB infection occurring in the setting of HIV infection [1,10]. The HCHB in this case heralded the presence of AIDS-defining opportunistic infections, which is a distinct stage of HIV disease [36] complicated by neurological abnormalities in as high as 60% of patients [4,37]. In patients with movement disorders associated with AIDS, identifying the opportunistic infection is the initial goal of management [4]. When HCHB occurs in this setting, a singular infectious etiology, primarily toxoplasmosis, is more commonly pursued which if negative, prompts consideration of alternative causes [1,4]. However, our case illustrates that in the appropriate clinical context, more than one intracranial infection is possible and should be sought. In contrast to published literature [1,4], HCHB in our case was from a cerebritis that may represent a beginning tuberculoma or a toxoplasmic abscess. Cerebritis is a nondescript area of parenchymal inflammation due to altered vascular permeability that heralds the development of an abscess and is seen on MRI as an area of hyperintensity on T2 weighted imaging, often with patchy contrast enhancement [38,39]. This is already a known early stage of toxoplasmic encephalitis [31] although other factors in our case led to the presumptive diagnosis of cerebral toxoplasmosis, namely, the presence of HCHB, multifocality of the brain lesions, T. gondii seropositivity and low CD4 count [31]. On the other hand, although TB cerebritis is very rare [39], the positive CSF TB PCR [35] and the MRI characteristics of the left frontal lobe lesion corroborated its tuberculous nature [40,41]. The rarity of TB cerebritis may be attributed to its delayed clinical presentation, which typically only manifests when mass effect ensues [42]. This case also demonstrates that a deep location as well as the presence of multiple focal tuberculous lesions may influence the appearance of movement disorders as suggested in Alarcón's cohort of 49 patients with tuberculoma [28]. Although we believe that both infections were contributory to the HCHB at the time of presentation, one limitation encountered was the lack of baseline neuroimaging, CD4 count and HIV viral load at the time of initial HIV and TB diagnosis, which could have helped elucidate the temporality of these infections in relation to HCHB.
Literature on concomitant intracranial co-infections in AIDS patients is limited, with a frequency of coexistent neurological diseases in this population ranging from 9% to 24% [31]. Currently, there are no studies describing their interplay as an underlying mechanism for HCHB, whether in the presence or absence of HIV infection. Acute disruption and altered firing rate of the STN and its efferent pathways due to a destructive focus, in addition to the direct effects of HIV on the basal ganglia circuitry, possibly contribute to the pathogenesis of chorea-ballism in this population [2,20,27,28,37,43]. As is usually the case among AIDS patients, multiple conditions may affect a portion of the nervous system simultaneously [36] and it is imperative to address these with adequate antimicrobial therapy.
The most effective treatment [4] in this case of coinfection remains to be trimethoprim/sulfamethoxazole [31], which is locally available, as well as HRZE [35]. The subsequent treatment response obviated the need for biopsy [31,44]. While we could not entirely discount its benefit in the acute phase, long-term symptomatic therapy with risperidone was no longer necessary in our case as this is commonly reserved for those with persistent or disabling symptoms [4,37]. Although response of chorea-ballism to antitoxoplasmosis and anti-TB therapy is variable [1,4,20], the marked improvement seen in our patient may attest to the reversible nature of AIDS-related HCHB, as is often seen after treatment [4]. Other factors that may affect overall prognosis of intracranial toxoplasmosis and TB include timing of diagnosis and therapy, clinical stage of the disease, and progression of neurological involvement [20,31,35].
In conclusion, this case demonstrates that HCHB may be the initial presentation of intracranial involvement of concomitant toxoplasmosis and TB in the setting of HIV infection. AIDS-related HCHB is potentially reversible with timely diagnosis and treatment.

ETHICS AND CONSENT
Consent was obtained from the patient in writing this report. All patients who appeared on video have provided written informed consent; authorization for the video recording and for publication of the video was provided.