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New Observations Letters

Paraneoplastic Chorea Managed with Intravenous Amantadine

Authors:

Nicholas Doher,

Department of Neurology, Kansas University Medical Center, Kansas City, KS, US
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Harsh V. Gupta

Department of Neurology, Kansas University Medical Center, Kansas City, KS, US
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Abstract

How to Cite: Doher N, Gupta HV. Paraneoplastic Chorea Managed with Intravenous Amantadine. Tremor and Other Hyperkinetic Movements. 2019;9. DOI: http://doi.org/10.5334/tohm.500
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  Published on 02 Dec 2019
 Accepted on 04 Nov 2019            Submitted on 23 Oct 2019

To the Editor,

We have read the article entitled ‘Anti-CV2/CRMP5 paraneoplastic chorea effectively managed with intravenous amantadine’ with great interest.1 We would like to congratulate the authors for this unique case report and make some suggestions.

In the case report, there was decreased radionucleotide uptake on an fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl)nortropane (FP-CIT PET) scan of the bilateral striatum that corresponded to severe atrophy and increased T2 signal on the magnetic resonance imaging (MRI) of the brain. This finding on FP-CIT PET imaging is expected given the structural abnormalities observed while conducting the MRI of the brain and therefore adds little diagnostic value. FP-CIT PET and other dopamine transporter (DaT) scan techniques are approved to only differentiate essential tremor from neurodegenerative disorders.2 An abnormality on structural imaging will always give false-positive results on positron emission tomography (PET) or single-photon emission computerized tomography (SPECT) and can lead to diagnostic confusion.3 There are many examples in literature of structural imaging abnormalities in the striatum with corresponding decreased uptake while using DaT scan techniques.48 It is important to stress that obtaining DaT scan imaging on a routine basis in patients diagnosed with structural abnormalities in the striatum upon conducting MRI is generally not indicated and can expose patients to unnecessary risk.

It should also be noted that there is some radiation exposure when a patient undergoes a DaT SPECT scan or PET scan. This can potentially increase the risk of cancer, especially in the elderly population.9

Notes

1 In Response To: 

Ha J, Na BS, Ahn JH, Kim M, Kim JW, Lee JH, et al. Anti-CV2/CRMP5 paraneoplastic chorea effectively managed with intravenous amantadine. Tremor Other Hyperkinet Mov. 2019: 9. doi: 10.7916/tohm.v0.701

2 Citation: Doher N, Gupta HV. Paraneoplastic chorea managed with intravenous amantadine. Tremor Other Hyperkinet Mov. 2019: 9. doi: 10.7916/tohm.v0.743. 

3 Editor: Elan D. Louis, Yale University, USA 

4 Funding: None. 

5 Financial Disclosures: None. 

6 Conflict of Interest: The authors report no conflict of interest. 

7 Ethics Statement: Not applicable for this category of article. 

References

  1. Ha, J , Na, BS , Ahn, JH , Kim, M , Kim, JW , Lee, JH , et al. Anti-CV2/CRMP5 paraneoplastic chorea effectively managed with intravenous amantadine. Tremor Other Hyperkinet Mov 2019;9. doi: https://doi.org/10.7916/tohm.v0.701 

  2. Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/022454Orig1s000Lbl.pdf [cited 21 October 2019]. 

  3. Tripathi, M , Jaimini, A , D'Souza, MM , Sharma, R , Jain, J , Garg, G , et al. Spectrum of brain abnormalities detected on whole body F-18 FDG PET/CT in patients undergoing evaluation for non-CNS malignancies. Indian J Nucl Med 2011;26(2):123–129. doi: https://doi.org/10.4103/0972-3919.9027122174526 

  4. Schirinzi, T, , Chiaravalloti, A, , Davoli, A , Pierantozzi, M, , Sancesario, G, Transient parkinsonism after unilateral midbrain stroke: a compensatory intervention from the healthy side? Neurol Sci 2014;35(2):2013–2015. doi: https://doi.org/10.1007/s10072-014-1836-z24852841 

  5. Colosimo, C “Abnormal” DaTSCAN in a case of unilateral hand tremor associated with caudate infarct. Parkinsonism Relat Disord 2010;16(5):356–357. doi: https://doi.org/10.1016/j.parkreldis.2010.02.00320189868 

  6. Teodoro, T , Lobo, PP , Ferreira, J , Sousa, R , Reimã;o, S , Peralta, R , et al. Delayed Parkinsonism after acute chorea due to non-ketotic hyperglycemia. J Neurol Sci 2015;354(1):116–117. doi: https://doi.org/10.1016/j.jns.2015.04.03925972111 

  7. Carrasco García de León, S, , Cabello, JP and , Ortiz, R, , Vaamonde, J, Parkinsonism associated with pathological 123I-FP-CIT SPECT (DaTSCAN) results as the initial manifestation of sporadic Creutzfeldt-Jakob disease. Case Rep Neurol Med 2018;2018:5157275. doi: https://doi.org/10.1155/2018/515727529955403 

  8. Rizzo, G, , Scaglione, C, , Lopane, G and , Pollini, A, , Tommasoni, E, , Martinelli, P, Parkinsonism in Caplan’s syndrome. Neurol Sci 2006;27(1):67–69. doi: https://doi.org/10.1007/s10072-006-0567-116688603 

  9. de la Fuente-Fernández, R Role of DaTSCAN and clinical diagnosis in Parkinson disease. Neurology 2012;78(10):696–701. doi: https://doi.org/10.1212/WNL.0b013e318248e52022323748 

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