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Author Response to Letter to the Editor

Authors:

Victoria Castrillo-Fraile ,

Department of Rehabilitation, Burgos University Hospital, Burgos; Department of Health Science, University of Valladolid, Valladolid, ES
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Elena Casas Peña,

Department of Neurology, Burgos University Hospital, Burgos, ES
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José María Trejo Gabriel y Galán,

Department of Neurology, Burgos University Hospital, Burgos, ES
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Pedro David Delgado-López,

Department of Neurosurgery, Burgos University Hospital, Burgos, ES
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Carla Collazo,

Department of Health Science, University of Burgos, Burgos, ES
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Esther Cubo

Department of Neurology, Burgos University Hospital, Burgos; Department of Health Science, University of Burgos, Burgos, ES
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Abstract

How to Cite: Castrillo-Fraile V, Peña EC, Gabriel y Galán JMT, Delgado-López PD, Collazo C, Cubo E. Author Response to Letter to the Editor. Tremor and Other Hyperkinetic Movements. 2020;10. DOI: http://doi.org/10.5334/tohm.531
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  Published on 28 Feb 2020
 Accepted on 04 Nov 2019            Submitted on 04 Nov 2019

Dear Editor:

We deeply appreciate the comments provided by López-Blanco et al. regarding our recent publication entitled “Tremor Control Devices for Essential Tremor: A Systematic Literature Review.”1

We basically agree with the aspects highlighted by these authors; however, we would like to discuss them briefly.

First, the main objective of our systematic literature review was to conduct a literature search about tremor-control devices using standardized criteria regarding efficacy and comfort in patients diagnosed with essential tremor (ET). We did not include computer software/hardware to control kinetic tremor by using the mouse of a PC, because the scientific literature supporting this technology have included patients with multiple sclerosis exclusively.2,3 We also excluded websites that did not include peer-review literature supporting effectiveness.3

Second, we fully agree with their second statement regarding the lack of publications of negative studies, and independent testing outside the initial developers.3 It would be interesting to study whether publication bias is more prevalent among nonpharmacologic interventions as compared to drugs in tremor and other neurological related fields.4

Third, we also agree on the importance of duration of clinical trials aimed to analyze the inherent variability of tremor intensity during testing. In order to study the effectiveness of tremor-suppression devices in ET, the functional impairment should ideally be studied at home, or at least, in a friendly environment, either in a natural/casual setting or under carefully-controlled circumstances in the lab, for a certain amount of time, to reduce tremor fluctuations due to confusing factors (pharmacological treatment effects, anxiety, etc.).

We appreciate the above comments provided by López-Blanco et al. which definitively improve the discussion of our article and highlight the importance of well-designed pharmacological and nonpharmacological clinical trials in ET.

Notes

1 In Response To: 

López-Blanco R, Benito-León J, Hernández-Gallego J & Sánchez-Ferro A. The validation of tremor cancelling technologies needs multidisciplinary consensus statement. Tremor Other Hyperkinet Mov. 2020; 10. doi: 10.7916/tohm.v0.765

2 Original Article: 

Castrillo-Fraile V, Peña EC, Gabriel y Galán JMT, Delgado-López PD, Collazo C & Cubo E. Tremor control devices for essential tremor: a systematic literature review. Tremor Other Hyperkinet Mov. 2019; 9. doi: 10.7916/tohm.v0.688

3 Citation: Castrillo-Fraile V, Casas-Peña E, Trejo Gabriel y Galán JM, Gabriel y Galán JMT, Delgado-López PD, Collazo C & Cubo E. Author Response to Letter to the Editor. Tremor Other Hyperkinet Mov. 2020; 10. doi: 10.7916/tohm.v0.770 

4 Editor: Elan D. Louis, Yale University, USA 

5 Funding: None. 

6 Financial Disclosures: None. 

7 Conflicts of Interest: None. 

8 Ethics Statement: None. 

References

  1. Castrillo-Fraile, V, , Peña, EC, , Gabriel Y Galán, JMT and , Delgado-López, PD, , Collazo, C, , Cubo, E, Tremor control devices for essential tremor: a systematic literature review. Tremor Other Hyperkinet Mov 2019;9:1–6. 

  2. Rocon, E, , Miranda, JA , Pons, JL, TechFilter: filtering undesired tremorous movements from PC mouse cursor. Technol Disabil 2006;18(1):3–8. doi: https://doi.org/10.3233/TAD-2006-18101 

  3. SteadyMouse, LLC The Steady Mouse Project [Internet]. 2019 Available from: https://www.steadymouse.com/ [cited 28 Dec 2019] 

  4. Petty, S and , Gross, RA, Neurology® null hypothesis: a special supplement for negative, inconclusive, or confirmatory studies. Neurology 2018;91(1):12–13. doi: https://doi.org/10.1212/WNL.000000000000580329884738 

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