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Correction: Can Plasma α-Synuclein Help Us to Differentiate Parkinson’s Disease from Essential Tremor?

Authors:

Silvia M. Albillos ,

Area of Biochemistry and Molecular Biology, University of Burgos, Pza. Misael Bañuelos s/n. 09001, Burgos, ES
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Olimpio Montero,

Consejo Superior de Investigaciones Científicas (CSIC). Av. Francisco Vallés, 8. 47151, Boecillo (Valladolid), ES
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Sara Calvo,

Research Unit of the Universitary Hospital of Burgos. Avda. de las Islas Baleares, 3. 09006, Burgos, ES
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Berta Solano,

Neurology Department of the Universitary Hospital Josep Trueta. Avinguda de França, S/N, 17007 Girona, ES
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José María Trejo,

Avda. de las Islas Baleares, 3. 09006, Burgos, Avda. de las Islas Baleares, 3. 09006, Burgos, ES
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Esther Cubo

Avda. de las Islas Baleares, 3. 09006, Burgos, Avda. de las Islas Baleares, 3. 09006, Burgos, ES
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Abstract

This article details a correction to: Albillos SM, Montero O, Calvo S, Solano B, Trejo JM, Cubo E. Can Plasma α-Synuclein Help Us to Differentiate Parkinson’s Disease from Essential Tremor? Tremor and Other Hyperkinetic Movements. 2021; 11(1): 20, pp. 1–8. DOI: https://doi.org/10.5334/tohm.600

How to Cite: Albillos SM, Montero O, Calvo S, Solano B, Trejo JM, Cubo E. Correction: Can Plasma α-Synuclein Help Us to Differentiate Parkinson’s Disease from Essential Tremor?. Tremor and Other Hyperkinetic Movements. 2021;11(1):24. DOI: http://doi.org/10.5334/tohm.637
  Published on 25 Jun 2021
 Accepted on 08 Jun 2021            Submitted on 08 Jun 2021

Correction

In Table 1 of Albillos et al. [1] there is no Off-State N = 33 value of NMSS total score and of PDCRS total score.

Table 1

Comparison of participant’s characteristics.


NOVO-PD
N = 19
PD
N = 35
ET
N = 19
CONTROLS
N = 35
P-VALUE

ON-STATE OFF-STATE

Males (%) 13 (68) 24 (69) 22 (67) 12 (63) 11 (31) 0.01

Age (years)a 66.9 (8.8) 64.5 (9.1) 64.1 (9.0) 70.8 (6.7) 61.4 (7.3) 0.002

Disease duration (years) 1 (0.6; 3) 10 (2; 25) 7 (1; 29)

UPDRS-III score 20 (8; 41) 24 (5; 49) 35 (12; 70) 0.01

NMSS total score 42 (24; 86) 69 (12; 119) 0.08

PDCRS total score 74 (58; 112) 80 (43; 109) 0.91

Values are expressed in medians (interquartile range) otherwise specified a = mean (Standard deviation). Parkinson’s disease (PD) (total sample = 35) measured in the ON state (ON-PD) (n = 35) and OFF state (OFF-PF), (n = 33); ET = Essential Tremor; UPDRS = Unified Parkinson’s disease Rating Scale; NMSS = Non motor symptoms severity score: PDCRS = Parkinson’s disease cognitive rating scale. Data were compared using the ANOVA test.

In Table 2, the values of α-Synuclein are quoted in ng/ml. The label of the first cell of the last row is ‘Pairwise comparisons’ and should read (1) vs. (5), (2) vs. (4), and (3) vs. (5) (second cell), (1) vs. (2) and (1) vs. (3) (third cell) and (1) vs. (2), (1) vs. (4), and (3) vs. (4) (fifth cell).

Table 2

Plasma α-synuclein quantitation (ng/ml) stratified by age and gender.


GROUPS α-SYNUCLEIN (ng/ml)
MEAN ± SD
p-VALUE α-SYNUCLEIN (ng/ml)
MEAN ± SD
P-VALUE


MEN
(n)
WOMEN
(n)
<66 YEARS OLD
(n)
≥66 YEARS OLD
(n)

CONTROL (1) 158.40 ± 102.95
(11)
177.12 ± 86.53
(24)
0.57 174.81 ± 94.85
(25)
162.32 ± 84.18
(10)
0.71

ON-PD (2) 112.30 ± 56.63
(23)
111.08 ± 40.45
(10)
0.95 125.76 ± 56.77
(17)
97.24 ± 42.45
(16)
0.11

OFF-PD (3) 128.64 ± 46.37
(21)
127.26 ± 29.16
(10)
0.92 137.40 ± 43.43
(16)
118.37 ± 37.40
(15)
0.20

NOVO-PD (4) 91.92 ± 35.28
(13)
131.25 ± 50.01
(6)
0.06 90.21 ± 26.38
(7)
112.58 ± 49.91
(12)
0.21

ET (5) 79.74 ± 32.11
(12)
143.73 ± 71.89
(6)
0.08 54.33 ± 1.95
(2)
106.92 ± 56.94
(16)

Pairwise comparisons (1) vs. (5)(2) vs. (4)(3) vs. (5) (1) vs. (2)(1) vs. (3) <0.05* (1) vs. (2)(1) vs. (4)(3) vs. (4) n.s <0.05*

SD = Standard deviation. Age was stratified based on the median distribution of the total sample. * Pairwise intra-group comparisons as indicated in each column; n.s = not significant.

The correct tables are included here.

This information was not included correctly in the final versions sent by the authors.

Competing interests

The authors have no competing interests to declare.

References

  1. Albillos SM, Montero O, Calvo S, Solano B, Trejo JM, Cubo E. Can Plasma α-Synuclein Help Us to Differentiate Parkinson’s Disease from Essential Tremor? Tremor and Other Hyperkinetic Movements. 2021; 11(1): 20, pp. 1–8. DOI: https://doi.org/10.5334/tohm.600 

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