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Further Evidence for Celiac Disease-associated Chorea?


Ruth H. Walker

Departments of Neurology, James J. Peters Veterans Affairs Medical Center, Bronx, New York; Mount Sinai School of Medicine, New York, US
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Background: A number of neurological conditions have been reported to be associated with gluten sensitivity, including ataxia, peripheral neuropathy, epilepsy, and occasionally, chorea. The pathogenic role of anti-gliadin antibodies has been questioned, and pathophysiology remains controversial.

Case Report: I report chorea in a patient with celiac disease, which responded to a gluten-restricted diet. The response of the movement disorder to change in diet strongly suggests a functional role for anti-gliadin antibodies in the generation of chorea, probably involving basal ganglia targets.

Discussion: Gluten sensitivity may be a treatable cause of chorea.

How to Cite: Walker RH. Further Evidence for Celiac Disease-associated Chorea?. Tremor and Other Hyperkinetic Movements. 2011;1:tre-01-32-96-3. DOI:
Published on 12 Dec 2011.
Peer Reviewed


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