Negative Myoclonus Induced by Ciprofloxacin

  • Anusha van Samkar
  • Floriaan G.C.M. De Kleermaeker
  • Margot G.E. te Riele
  • Aad Verrips


Background: Negative myoclonus is characterized by a brief sudden loss of muscle activity, and can be caused by a variety of acquired factors and epilepsy syndromes.

Phenomenology Shown: We show a clear video example of a patient with an extensive negative myoclonus that was induced by ciprofloxacin.

Educational Value: Several neurotoxic effects have been associated with the use of ciprofloxacin, but negative myoclonus has not been reported previously.