Orofacial Involuntary Movements in Neurosyphilis: Beyond the Candy Sign

  • Abhishek Lenka
  • Naveen Thota
  • Albert Stezin
  • Pramod Kumar Pal
  • Ravi Yadav


Background: Involvement of the central nervous system in patients with syphilis (neurosyphilis) may result in several neuropsychiatric symptoms. Rarely, patients with neurosyphillis may develop movement disorders with different phenomenology. Subtle orofacial dyskinesias have been reported in patients with neurosyphilis, known as the candy sign.

Case Report: We describe a patient with neurosyphilis who presented with severe orofacial involuntary movements.

Discussion: Our patient had orofacial movements at presentation and severity of the movements was much higher than the candy sign that has been reported in patients with neurosyphilis. This report contributes towards the ever-expanding clinical spectrum of neurosyphilis.