Tremor and Other Hyperkinetic Movements

Anti-GAD Antibody-associated Syndrome Presenting with Limb Myoclonus

Pedro Manzke, Talyta Grippe, Georgia L. Tavares, Lucas C. Leal, Emmanuel Roze, Emmanuelle Apartis, Ronaldo M. Dias, André G. Ferreira


Background: The clinical spectrum of anti-glutamic acid decarboxylase (GAD) antibody-associated neurologic syndromes is expanding, with focal, generalized, and atypical forms.

Case Report: We describe a 59-year-old female showing continuous right lower limb myoclonus and mild encephalopathy. These symptoms started 2 weeks prior to evaluation. The patient had great improvement with intravenous steroids. An autoantibody panel was positive for anti-GAD.

Discussion: Various clinical manifestations, including myoclonus, may relate to anti-GAD antibodies. The treatment options available include symptomatic drugs, intravenous immunoglobulin, steroids, and other immunosuppressant agents.



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