The Prevalence and Correlation of Non-motor Symptoms in Adult Patients with Idiopathic Focal or Segmental Dystonia
Background: Idiopathic focal dystonia is a motor syndrome associated with dysfunction of basal ganglia circuits. Observations have suggested that many other non-motor symptoms may also be part of the clinical picture. The aim was to assess the prevalence and correlation of non-motor symptoms in patients with common idiopathic focal or segmental dystonia.
Methods: In a single-center cross-sectional case–control study, we evaluated the presence of pain, neuropsychiatric symptoms, and sleep alterations in 28 patients with blepharospasm, 28 patients with cervical dystonia, 24 patients with writer’s cramp, and 80 control subjects matched for sex, age, and schooling. We obtained clinical and demographic data, and evaluated patients using the Fahn–Marsden Dystonia Rating Scale and other specific scales for dystonia. All subjects completed the following questionnaires: Beck Depression Inventory, Beck Anxiety Inventory, Social Phobia Inventory, Apathy Scale, Epworth Sleepiness Scale, Pittsburgh Sleep Quality Index, Brief Pain Scale, and the World Health Organization Quality of Life brief scale.
Results: The patients presented more symptoms of depression, anxiety, and apathy than the control subjects. They also reported worse quality of sleep and more pain complaints. Patients with blepharospasm were the most symptomatic subgroup. The patients had worse quality of life, and the presence of pain and symptoms of apathy and depression were the main influences for these findings, but not the severity of motor symptoms.
Discussion: Patients with dystonia, especially those with blepharospasm, showed higher prevalence of symptoms of depression, anxiety, apathy, worse quality of sleep, and pain. These symptoms had a negative impact on their quality of life.
Keywords: Dystonia, non-motor symptoms, depression, apathy, sleep, pain
Citation: Novaretti N, Cunha ALN, Bezerra TC, Pereira MA, de Oliveira D, Macruz Brito MMC, et al. The prevalence and correlation of non-motor symptoms in adult patients with idiopathic focal or segmental dystonia. Tremor Other Hyperkinet Mov. 2019; 9. doi: 10.7916/fhnv-v355
*To whom correspondence should be addressed. E-mail: firstname.lastname@example.org
Editor: Elan D. Louis, Yale University, USA
Received: August 1, 2018 Accepted: December 14, 2018 Published: February 4, 2019
Copyright: © 2019 Novaretti et al. This is an open-access article distributed under the terms of the Creative Commons Attribution–Noncommercial–No Derivatives License, which permits the user to copy, distribute, and transmit the work provided that the original authors and source are credited; that no commercial use is made of the work; and that the work is not altered or transformed.
Financial Disclosures: None.
Conflicts of Interest: The authors report no conflict of interest.
Ethics Statement: This study was performed in accordance with the ethical standards detailed in the Declaration of Helsinki. The authors’ institutional ethics committee has approved this study and all patients have provided written informed consent.
Dystonia is a movement disorder characterized by sustained and/or intermittent muscle contractions causing abnormal, often repetitive, movements, postures, or both.1 Focal isolated dystonia is the most common form of dystonia in adulthood, with symptom onset usually in the fifth decade of life. Most of these cases are idiopathic and may present as cervical dystonia, blepharospasm, or writer’s cramp.2 Idiopathic focal dystonia in adults rarely progresses to generalized dystonia, but may spread to contiguous regions and become a segmental form.3 Despite the localized distribution of abnormal movements, focal dystonia affects functional aspects of daily living and social functioning, and significantly impairs quality of life.4
Although dystonia presents characteristically as a clinical motor problem, many studies have suggested that several non-motor symptoms can often be observed in these patients and may be relevant predictors of their quality of life.4,5 Among these, some neuropsychiatric symptoms such as depression, anxiety, apathy, and obsessive–compulsive behaviors can be highlighted. Additionally, these patients also report having sleep disorders and pain.6–8 These non-motor symptoms might be because dystonia may cause functional disability and negative body perception, which could lead to the appearance of symptoms of anxiety and depression. On the other hand, non-motor symptoms may relate primarily to the pathophysiology of dystonia itself.
The pathophysiology of dystonia is not completely understood, but is considered to be related to dysfunctions of the basal ganglia system and its connections, mainly to the thalamus and brainstem.9 It has also been correlated with dysfunction of the cerebellum, one of the most prominent brain structures associated with motor control.10 Furthermore, several non-motor symptoms of dystonia may be due to abnormal functioning of cortical, limbic, basal ganglionic, and cerebellar loops.
Most studies published so far have focused only on a specific group of non-motor symptoms, without assessing the correlations between the most prevalent ones, and some have reported contrary findings.11 Since these symptoms can significantly influence patients’ quality of life, it is extremely important to gain better understanding of this issue. The present study aimed to evaluate the prevalence of neuropsychiatric symptoms, sleep disturbances, and pain in a sample of patients with idiopathic focal or segmental dystonia, and to investigate correlations between these symptoms and their impact on quality of life.
This was a case–control cross-sectional single-center study conducted on Brazilian patients. For our study, we initially recruited 160 participants. Out of that group, 80 were control subjects. The remaining 80 participants were consecutive patients with various forms of idiopathic focal or segmental dystonia. All participants were over 18 years old. The exclusion criteria in both groups were the presence of dementia, any other neurological disorder or any serious or decompensated systemic disease.
Patients were recruited from the outpatient clinic for movement disorders at the Ribeirão Preto School of Medicine. All participants agreed to participate in this study. They were all diagnosed with a common form of adult-onset idiopathic focal or segmental dystonia, with confirmation from a movement disorder specialist. All patients who were regularly undergoing treatment with botulinum toxin type A were evaluated at least 13 weeks after the last application. In addition, if the patient was using any other medication for dystonia, the treatment was continued.
The control group was matched for sex, age, and years of education (schooling). Control participants were selected from among the individuals who accompanied the patients with movement disorders to their appointments and from among hospital staff members. The objective of the study was explained to these individuals and they were asked if they were willing to voluntarily collaborate in the study as a control group to be compared with the patients in the study. The exclusion criteria were the same as in the group of patients, but individuals with pathological conditions were not excluded, even if chronic, if that condition was adequately controlled; those with previous psychiatric conditions were not excluded. If a participant in the control group presented altered scores on the scales evaluated, this individual would be referred for medical follow-up.
This study was approved by the local Ethics Committee of the Ribeirão Preto School of Medicine hospital (protocol number 12736/2011) and was conducted in accordance with the ethical principles of the Declaration of Helsinki. All subjects signed an informed consent statement before participating.
A clinical evaluation was conducted by a neurologist who was a specialist in movement disorders in order to obtain clinical and demographic data from the patients and control subjects. The severity of dystonia was determined using the Fahn–Marsden Dystonia Rating Scale.12 We evaluated patients with blepharospasm using the Jankovic Rating Scale and the Blepharospasm Disability Index,13 patients with cervical dystonia using the Tsui Rating Scale,14 and patients with writer’s cramp using the Writer’s Cramp Rating Scale and the Arm Dystonia Disability Scale.15,16
We assessed non-motor symptoms using clinical scales that had been validated for the Brazilian population. Cognition was assessed by means of the Mini Mental State Examination.17 The Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI) were used to determine self-reported levels of depression and anxiety.18,19 The Social Phobia Inventory was used to identify subjects with suspected social phobia.20 Symptoms of apathy were evaluated using the Apathy Scale (AS).21
We evaluated the presence of pain over the previous 3 months by using a structured questionnaire based on the Brief Pain Scale24 (prevalence, monthly frequency, intensity according to a numerical visual scale, and site affected according to a drawing of the specific location). The World Health Organization Quality of Life brief scale (WHOQOL-BREF) was used to evaluated quality of life.25
All subjects were evaluated in either one or two sessions. They were initially instructed to provide self-reported responses to the questionnaires. The examiner then checked the responses and, if necessary (in cases in which patients were unable to respond to all the questions or if there were any doubts), the questionnaire was reapplied. In cases of inability to use self-reported scales (due to severe dystonia or low education levels), a trained examiner applied the instruments to the subject.
We performed descriptive analysis on all the clinical data. For comparisons between groups, two comparative analyses were performed.
Firstly, we compared all the patients versus the control group. To compare numerical variables, we used analysis of variance, followed by the Bonferroni post hoc test when appropriate. For categorical data, we used the exact chi-square test and odds ratio estimates through binary logistic regression.
We then compared all three subtypes of dystonia with the controls, simultaneously. Non-adjustment was made with regard to matching for sex, age, and schooling levels between these groups. In this analysis, we used multivariate analysis of covariance, followed by the Bonferroni post hoc test when appropriate. The factors analyzed were groups and sex, as categorical variables, and age and schooling as numerical covariates. For the categorical data, we used the exact chi-square test and odds ratio estimates through binary logistic regression.
The Spearman rank correlation test was used to evaluate associations between the motor scales.
The data were expressed as mean±SD, and p < 0.05 was assumed to be statistically significant. The data were analyzed using SPSS 17.0 statistical software (IBM, USA).
We evaluated 80 patients and 80 control subjects. The patients group consisted of 28 patients with blepharospasm, including five patients with cranial dystonia (group 1); 28 patients with cervical dystonia, including five patients with craniocervical dystonia (group 2); and 24 patients with limb dystonia, including 22 with writer’s cramp, one with leg dystonia and one with arm dystonia (group 3). Table 1 presents the clinical characteristics and demographic data on all the patients and control subjects.
Abbreviations: AS, Apathy Scale; BAI, Beck Anxiety Inventory; BDI, Beck Depression Inventory; ESS, Epworth Sleepiness Scale; FMDRS, Fahn–Marsden Dystonia Rating Scale; MMSE, Mini Mental State Examination; NVS, Numeric Visual Scale; PSQI, Pittsburgh Sleep Quality Index; SPIN, Social Phobia Inventory; WHOQOL-BREF, World Health Organization Quality of Life Brief Scale.
Data were compared using analysis of variance and chi-square.
aDifferent from the other group (p ≤ 0.05).
|% with comorbidities||51.2||68.7a||0.024|
|% with use of benzodiazepines||18.7||11.2||0.184|
|% with use of antidepressants||23.7a||11.2||0.038|
|Duration of disease (years)||12.8±9.7||–||–|
|Age at disease presentation||45.8±13.3||–||–|
|Pain, NVS scores||6.6±2.5a||5.3±2.4||0.018|
|% with pain||80a||50||0.001|
Comparing all the patients with the control group, there were no significant differences between the groups according to age, gender, schooling, or Mini-Mental State Examination scores. The patients had presented dystonia for 10–15 years and were using antidepressants more frequently than were the controls (p = 0.038).
Both the majority of patients (n = 41) and the majority of participants in the control group (n = 55) had at least one comorbidity (p = 0.024). Cardiovascular diseases were predominant in both groups with comorbidities of patients (58.5%) and control participants (63.6%) (p = 0.612), followed by endocrine and metabolic diseases (46.3% and 38.2%, respectively, p = 0.422), and neuropsychiatric diseases (39% and 23.6%, p = 0.104).
We found significant differences between the groups regarding their scores from the BDI, BAI, AS, PSQI, and Numerical Visual Scale for pain; however, there were no differences between the groups regarding their scores from the Social Phobia Inventory and Epworth Sleepiness Scale (Table 1).
In the BDI, the patients had higher scores than the controls. They presented more than twice the risk of having a depressive symptom (BDI ≥ 12) (p = 0.004; odds ratio [OR] = 2.58; 95% confidence interval [CI] = 1.32–5.04), and more of them presented moderate and severe depressive symptoms (BDI ≥ 20) (p = 0.024). They also presented higher scores in the BAI than did the controls, with a higher chance of presenting a symptom of anxiety (BAI ≥ 8) (p = 0.001; OR = 3.58; 95% CI = 1.67–7.67).
From analysis of the AS, the patients showed significantly higher scores (p = 0.002) and their risk of apathy (AS ≥ 14) was three times higher than that of the controls (p = 0.002; OR = 2.96; 95% CI = 1.49–5.87). Moreover, they presented higher scores in the PSQI than did the controls, and their sleep quality was more frequently impaired (PSQI > 5) than was that of the controls (p = 0.007; OR = 2.37; 95% CI = 1.25–4.47). Multivariate regression analysis showed that the BDI and BAI scores (p = 0.004 and p < 0.001) influenced the PSQI scores, whereas there was no effect on pain (p = 0.485) or the use of antidepressants among the subjects (p = 0.730).
The dystonic patients presented significantly more intense and frequent pain than did the controls. They were 2.5 times more likely to complain of pain than were the controls (p = 0.019; OR = 2.58; CI = 1.16–5.71). Most of those with cervical dystonia (87%) and writer’s cramp (76%) reported having pain at the site of their dystonic movements, while most of the patients with blepharospasm (67%) reported having pain in other parts of the body.
The patients with dystonia presented lower total scores in the WHOQOL-BREF measurement than those of the controls (Table 1). They showed lower scores in physical and psychological evaluations, but not in the social relationship or environmental domains. In multivariate analysis, the presence of pain (p = 0.029), BDI scores (p < 0.001), AS scores (p < 0.001), and type of dystonia (p = 0.015) influenced the WHOQOL-BREF total score, but there was no influence on the severity of motor symptoms measured by the Fahn–Marsden Dystonia Rating Scale (p = 0.198).
Comparing the patient subgroups with the control group, group 3 was the only group in which males predominated. Group 1 was significantly older, with lower schooling and lower Mini-Mental State Examination scores than either of the other two subgroups of patients or the controls. Schooling (p < 0.001) and age (p = 0.046) influenced the Mini-Mental State Examination scores of the patients, but there was no influence from the type of dystonia (p = 0.854).
The Fahn–Marsden Dystonia Rating Scale scores correlated significantly with the scores on the scores on the Jankovic Rating Scale (p = 0.0001; correlation coefficient (cc) = 0.71), Arm Dystonia Disability Scale (p = 0.0001; cc = –0.77), Writer’s Cramp Rating Scale part B (p = 0.01; cc = –0.53), and Tsui Rating Scale (p = 0.02; cc = –0.42). However, there were no correlations with the scores on the Blepharospasm Disability Index (p = 0.15; cc = 0.27) or the Writer’s Cramp Rating Scale part A (p = 0.15; cc = –0.31). These observations suggest that the scores on the Fahn–Marsden Dystonia Rating Scale generally reflected the severity of dystonia in the different groups of patients. Group 1 and group 2 did not show any difference in their Fahn–Marsden Dystonia Rating Scale scores, while group 3 presented lower scores than either of the other subgroups (p = 0.013).
In a group analysis, we found that the prevalence of psychiatric symptoms presented by group 3 was not as high as the prevalence among the patients in groups 1 and 2. Group 1 had higher BDI scores than those of all the other groups. They also showed higher BAI and AS scores than those of group 3 and the controls (Table 2).
|Group 1||Group 2||Group 3||Group 4||dF||F||p|
Abbreviations: AS, Apathy Scale; BAI, Beck Anxiety Inventory; BDI, Beck Depression Inventory; dF, degrees of freedom; ESS, Epworth Sleepiness Scale; F, multivariate F value; MMSE, Mini Mental State Examination; PSQI, Pittsburgh Sleep Quality Index; SPIN, Social Phobia Inventory; WHOQOL-BREF, World Health Organization Quality of Life Brief Scale.
Date were compared using multivariate analysis of covariance.
Group 1, blepharospasm patients; group 2, cervical dystonia patients; group 3, writer’s cramp patients; group 4, control subjects.
ap ≤ 0.05.
Group 1 was five times more likely to experience pain than were the controls (p = 0.006; OR = 5.38; 95% CI = 1.63–17.78). Their risk of having pain symptoms was higher than that observed for group 2 (p = 0.005; OR = 4.63; 95% CI = 1.59–13.49) or group 3 (p = 0.056; OR = 2.72; 95% CI = 0.97–1.02). The Fahn–Marsden Dystonia Rating Scale scores did not affect the results from the BDI and BAI, AS, or PSQI (p = 0.328), or the presence of pain (p = 0.250).
Group 2 showed higher BAI scores and higher AS scores than the controls. Groups 2 and 3 presented higher PSQI scores than the controls (Table 2).
From analysis on all the different subgroups, we observed that group 1 was the most affected in terms of quality of life, which includes the physical and social relationship domains. Groups 1 and 2 were equally affected in regard to the physical domain compared with the controls, while group 3 was the least affected in all domains (Table 2).
Our study confirmed previously published observations that indicated that non-motor symptoms are more prevalent in patients with idiopathic focal or segmental dystonia. Our patients with blepharospasm, cervical dystonia, and writer’s cramp presented more symptoms of depression, anxiety, apathy, pain, and impaired sleep quality than did the control subjects. Nonetheless, despite having poor sleep quality, they did not complain of excessive daytime sleepiness. In addition, even though they showed more anxiety symptoms, the incidence of social phobia was not higher.
Several studies have already indicated that the prevalence of depressive symptoms in patients with dystonia is higher, thus indicating that depression is probably a common clinical problem associated with this disorder.6,8,11,26 However, for some authors, the association between dystonia and anxiety was not very well defined.11
In our sample, patients with focal dystonia presented significantly more symptoms of anxiety than did the controls. This was also observed in some other recent studies.7,8,26 Only one study did not find any association between symptoms of anxiety and dystonia.6 Despite these contradictory findings, most recent studies corroborate the notion that there is an association between dystonia and symptoms of anxiety. We did not find higher levels of symptoms of social phobia among our patients; however, there was a statistical trend towards this. Other studies have also indicated a high frequency of social phobia among patients with cervical dystonia.27,28 We also observed higher prevalence of symptoms of apathy in our patients, as also described previously.29
Pain and discomfort are common symptoms among patients with focal dystonia.11 Most of our patients presented pain, and, in most cases, this was related to the body region affected by dystonic movements, as already described in other studies.5 Pain is usually evident in the body region affected by dystonia; however, pain levels do not always correlate with the objective severity of neurological signs, as we also observed in our sample.30 However, treatment of dystonia through local injections of botulinum toxin clearly reduces pain in these patients.31 Some studies have suggested that pain thresholds are lower in patients with dystonia than in healthy controls.32
Voxel-based analyses showed a reduction in gamma-aminobutyric acid (GABA) receptor expression in the primary motor cortex, pre-motor cortex, secondary somatosensory cortex, and motor component of the cingulate gyrus in patients with early-onset generalized torsion dystonia (DYT-TOR1A) and sporadic dystonia that could lead to a lower threshold for pain.33 We observed in our sample that more than half of our patients with blepharospasm also complained of pain that was unrelated to the site of dystonia. This finding might be related to the fact that these patients were older than the others, and other causes of pain associated with aging could be responsible for these symptoms. Further studies to clarify the mechanisms of pain associated with dystonia are needed.
Our patients presented lower sleep quality than that of the control subjects. Nevertheless, they did not show higher rates of daytime sleepiness. Other studies found the same results.11,34,35 The authors of a systematic review on sleep disorders in cases of dystonia suggested that sleep disturbances among these patients could have many origins, such as the same pathophysiological mechanisms that produce dystonia, medications, pain, the abnormal movements themselves, or psychosocial stress.36 In our sample, symptoms of anxiety and depression especially influenced sleep quality, but not pain or the use of antidepressants. Our findings support the hypothesis that psychiatric disorders may be a significant factor related to the worsened quality of sleep of patients with dystonia.
One of the major difficulties in studying non-motor symptoms in movement disorders is the high prevalence of comorbidities and the interaction between these diseases and their symptoms. Just as insomnia can be a disease by itself, it can also be a symptom of depression or secondary to pain. Studying various non-motor symptoms together may be one way to evaluate these interactions and better understand what would be related to the pathophysiology of dystonia and what would be the consequence of this chronic disease.
Patients with dystonia may present non-motor symptoms for several reasons. In addition, some non-motor symptoms may interact with each other to cause or worsen other symptoms. Some of these might mainly be consequences of psychosocial effects relating to dystonia itself; however, dysfunctions in the basal ganglia circuits could be the cause of several of these non-motor symptoms.
We did not design our study to answer these questions, and further studies are needed in order to understand the mechanisms underlying these effects. However, our findings suggest that physical alterations caused by dystonia might also have been responsible for some of our patients’ psychiatric complaints, as such complaints were more frequent among patients with blepharospasm and cervical dystonia than among those with writer’s cramp. Among patients with blepharospasm, some authors have suggested that depression may be a cause of the facial feedback.37
A recent study sought to assess correlations between psychiatric symptoms and dopaminergic dysfunction in movement disorders. It was found that patients with dystonia presented an inverse association between the severity of depressive and anxiety symptoms and the availability of dopaminergic transporter in the left putamen.38 Striatum connections such as the prefrontal cortex, amygdala, and locus coeruleus connect neuronal networks relating to the pathophysiology of anxiety. Thus, it is possible that the psychiatric symptoms found in these patients were, in part, secondary to striatal pathway dysfunction. It can therefore be seen that the pathophysiology of non-motor symptoms in cases of dystonia is complex and depends on the interplay between various clinical factors and underlying abnormalities of the functioning of the basal ganglia.
Nevertheless, the negative impact of non-motor symptoms on the quality of life indicates the importance of investigating their presence in patients with dystonia, in order to plan individualized treatments. As shown in previous studies, we also observed that patients with common focal dystonia presented worse quality of life than that of control subjects.4,39 The domains most affected were physical and psychological. The severity of motor symptoms as measured using the Fahn–Marsden Dystonia Rating Scale was not a relevant predictor of quality of life in the way that some non-motor symptoms were, especially pain and depression. Additionally, we observed that there was a difference in the quality of life depending on the clinical form of focal dystonia. We believe that discrimination through these non-motor symptoms explains this observation.
This study was the first Brazilian study evaluating and correlating the non-motor symptoms among patients with idiopathic focal and segmental dystonia. We included a relatively large and selected sample, and used clinical scales that had been validated for the Brazilian population. However, we only included a small number of patients with each different subtype of dystonia and the patients were not subjected to psychiatric evaluation or polysomnography for a more detailed clinical analysis.
In conclusion, our study reinforces previous observations, thus indicating that there was higher prevalence of symptoms of depression, anxiety, apathy and pain, and poorer quality of sleep, among patients with focal dystonia. This study also showed that these symptoms could influence one another.
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