Increasing Evidence for the Use of Sodium Oxybate in Multi-Drug- Resistant Lance–Adams Syndrome

  • Giulietta M. Riboldi
  • Steven J. Frucht


Background: Treatment of posthypoxic myoclonus (PHM) can be a challenge in patients not responsive to first-line medications. PMH is a rare condition that has a dramatic impact on patients’ quality of life. Refractory cases are not uncommon.

Case Report: We report a patient with PHM non-responsive to conventional treatments who showed a dramatic improvement with sodium oxybate (SBX). Cases of PHM treated with SBX reported in the literature were reviewed.

Discussion: Resting and stimulus-induced myoclonus respond robustly to SBX, with significant improvement in patients’ quality of life. SBX may be considered in patients with PHM resistant to first-line medications.

Keywords: Posthypoxic myoclonus, Lance–Adams syndrome, refractory myoclonus, alcohol-sensitive myoclonus, sodium oxybate

Citation: Riboldi GM, Frucht SJ. Increasing Evidence for the Use of Sodium Oxybate in Multi-Drug-Resistant Lance–Adams Syndrome. Tremor Other Hyperkinet Mov. 2019; 9. doi: 10.7916/d8-rnsh-c024.